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ABC839 Anti-ATR Antibody

Anti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC.

Anti-ATR Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANTXR1, ATR, TEM8 UniProt Number: Q9H6X2
ABC839
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC839
DescriptionAnti-ATR Antibody
Alternate Names
  • Anthrax toxin receptor 1
  • Tumor endothelial marker 8
Background InformationThe Anthrax toxin receptor 1 (also known as Tumor endothelial marker 8, ANTXR1 and ATR) was initially discovered as the tumor endothelial marker (TEM8). This protein, which exists in three isoforms (33, 37, 41, and 63 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunocytochemistry
Application NotesImmunohistochemistry Analysis: 2 μg/mL from a representative lot detected ATR in human brain tissue.

Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected ATR in human brain cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 13 amino acids near the center region of human ATR.
EpitopeCenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • ANTXR1
  • ATR
  • TEM8
Purification MethodPurified by Ion-Exchange Chromatography
UniProt Number
Molecular Weight~41 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ATR in HepG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC839 04053252940637