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124011 Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Akt
124011
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Overview

Key Spec Table

CAS #Empirical Formula
681281-88-9C₃₁H₂₇IN₄S

Products

Catalogue NumberPackaging Qty/Pack
124011-1MG Glass bottle 1 mg
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124011-5MG Plastic ampoule 5 mg
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Description
OverviewA cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
Catalogue Number124011
Brand Family Calbiochem®
References
ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Product Information
CAS number681281-88-9
ATP CompetitiveN
FormYellow solid
Hill FormulaC₃₁H₂₇IN₄S
Chemical formulaC₃₁H₂₇IN₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAkt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
124011-1MG 04055977206357
124011-5MG 04055977205626