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533642 AMP Deaminase Inhibitor, Cpd3 - Calbiochem

AMP Deaminase Inhibitor, Cpd3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMP Deaminase Inhibitor, AMPD Inhibitor

533642
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₂₁N₃O₂

Products

Catalogue NumberPackaging Qty/Pack
5336420001 Glass bottle 5 mg
Description
OverviewA cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50 = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.
Catalogue Number533642
Brand Family Calbiochem®
Synonyms(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMP Deaminase Inhibitor, AMPD Inhibitor
References
ReferencesAdmyre, T., et al. 2014. Chem. Biol. 21, 1486.
Product Information
FormWhite solid
Hill FormulaC₂₄H₂₁N₃O₂
Chemical formulaC₂₄H₂₁N₃O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Target IC<sub>50</sub>38 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5336420001 04055977286571

Documentation

AMP Deaminase Inhibitor, Cpd3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AMP Deaminase Inhibitor, Cpd3 - Calbiochem Certificates of Analysis

TitleLot Number
533642

References

Reference overview
Admyre, T., et al. 2014. Chem. Biol. 21, 1486.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-September-2017 JSW
Synonyms(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMP Deaminase Inhibitor, AMPD Inhibitor
DescriptionA cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50 = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₁N₃O₂
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAdmyre, T., et al. 2014. Chem. Biol. 21, 1486.