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658403 AG 538 - CAS 133550-18-2 - Calbiochem

A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC₅₀ = 400 nM).

AG 538 - CAS 133550-18-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538

Primary Target: IGF-1 receptor kinase
658403
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
133550-18-2C₁₆H₁N₁₁O₅

Products

Catalogue NumberPackaging Qty/Pack
658403-5MG Plastic ampoule 5 mg
Description
OverviewA potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 µM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM).
Catalogue Number658403
Brand Family Calbiochem®
Synonymsα-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
References
ReferencesBlum, G., et al. 2000. Biochemistry 39, 15705.
Product Information
CAS number133550-18-2
ATP CompetitiveY
FormDark orange to brown solid
Hill FormulaC₁₆H₁N₁₁O₅
Chemical formulaC₁₆H₁N₁₁O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIGF-1 receptor kinase
Primary Target IC<sub>50</sub>400 nM against IGF-1 receptor kinase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658403-5MG 04055977261585

Documentation

AG 538 - CAS 133550-18-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 538 - CAS 133550-18-2 - Calbiochem Certificates of Analysis

TitleLot Number
658403

References

Reference overview
Blum, G., et al. 2000. Biochemistry 39, 15705.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2016 JSW
Synonymsα-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
DescriptionA potent, cell-premeable, reversible, and competitive inhibitor of IGF-1R (insulin-like growth factor-1 receptor) kinase autophosphorylation (IC50 = 400 nM). Also inhibits the phosphorylation of PTK substrate poly (Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, and 2.4 µM respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM). Inhibition is competitive with respect to the substrate binding site of IGF-1R kinase. Also inhibits the authophosphorylation of IGF-1R and the activation of PKB and ERK2 in NIH-3T3 cells over-expressing IGF-1R.
FormDark orange to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number133550-18-2
Chemical formulaC₁₆H₁N₁₁O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBlum, G., et al. 2000. Biochemistry 39, 15705.