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407293 α-Interferon, Mouse, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
407293
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
407293-100KU Plastic ampoule 100 ku
Description
OverviewRecombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units.
Catalogue Number407293
Brand Family Calbiochem®
References
ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
Dianzani, F. 1993. Gut 34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
Pestka, S. 1986. Methods Enzymol. 119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
Rubinstein, S., et al. 1981. J. Virol. 37, 755.
Product Information
Activity≥3.5 x 10⁴ units/ml
Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
FormLiquid
FormulationIn PBS containing 0.1% BSA.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407293-100KU 04055977188196

Documentation

α-Interferon, Mouse, Recombinant, E. coli SDS

Title

Safety Data Sheet (SDS) 

α-Interferon, Mouse, Recombinant, E. coli Certificates of Analysis

TitleLot Number
407293

References

Reference overview
Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
Dianzani, F. 1993. Gut 34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
Pestka, S. 1986. Methods Enzymol. 119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
Rubinstein, S., et al. 1981. J. Virol. 37, 755.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-December-2008 JSW
DescriptionRecombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.
FormLiquid
FormulationIn PBS containing 0.1% BSA.
Purity≥95% by SDS-PAGE
Activity≥3.5 x 10⁴ units/ml
Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
Merck USA index14, 4990
ReferencesKrishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer 61, 110.
Dianzani, F. 1993. Gut 34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science 208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res. 47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol. 119, 34.
Pestka, S. 1986. Methods Enzymol. 119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol. 78, 394.
Rubinstein, S., et al. 1981. J. Virol. 37, 755.