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23-049M p38/JTV-1 Protein, 250 µg

Full length, recombinant human p38/JTV-1. N-terminal cMyc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

p38/JTV-1 Protein, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays
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23-049M
250 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-049M
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp38/JTV-1 Protein, 250 µg
      Alternate Names
      • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
      • AIMP2
      • Multisynthase complex auxiliary component p38
      Background Informationp38/JTV-1 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex, an essential enzyme that ligates specific amino acids to tRNAs before protein synthesis. It plays a pivotal role in the control of cell proliferation and has been shown to interact with FUSE binding protein, stimulating its ubquitination and degradation and leading to the down-regulation of the transcription factor c-Myc which is required for differentiation of functional alveolar type II cells. Genetic disruption of p38/JTV-1 in mice has been observed to cause neonatal lethality.

      p38/JTV-1 is ubiquitinated by the E3 ligase Parkin, leading to its proteosomal degradation. It has been shown to accumulate in Parkin-deficient mice and in the brain tissue of patients with hereditary Parkinson’s, suggesting that it may play a role in the pathogenicity of this disease.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationFull length, recombinant human p38/JTV-1. N-terminal cMyc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      23-049M 04053252649943

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      23-049 p38/JTV-1 Protein, 10 µg Show Pricing & Availability

      Product Families

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      Categories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates