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676494 VEGF Inhibitor, Je-11 - Calbiochem

VEGF Inhibitor, Je-11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII

Primary Target: Binds to VEGF and blocks its interaction with VEGFR-2
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      Overview

      Key Spec Table

      Empirical Formula
      C₁₈₈H₂₇₃N₄₉O₅₇
      Description
      Overview

      This product has been discontinued.



      A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC).
      Catalogue Number676494
      Brand Family Calbiochem®
      Synonyms(RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
      References
      ReferencesPiossek, C., et al. 1999. J. Biol. Chem. 274, 5612.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₈₈H₂₇₃N₄₉O₅₇
      Chemical formulaC₁₈₈H₂₇₃N₄₉O₅₇
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetBinds to VEGF and blocks its interaction with VEGFR-2
      Primary Target IC<sub>50</sub>500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequence(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      676494 0