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676491 VEGF Inducer, GS4012 - CAS 328073-92-3 - Calbiochem

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012

Primary Target: Potent inducer of VEGF and VEGF-mediated vessel formation
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676491
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
328073-92-3C₁₄H₁₅NOS • HCl

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      Description
      OverviewA cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.
      Catalogue Number676491
      Brand Family Calbiochem®
      Synonyms4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
      References
      ReferencesPeterson, R.T., et al. 2004. Nat. Biotechnol. 22, 595.
      Depre, C., et al. 2003. Circulation 108, 2723.
      Product Information
      CAS number328073-92-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₁₅NOS • HCl
      Chemical formulaC₁₄H₁₅NOS • HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPotent inducer of VEGF and VEGF-mediated vessel formation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676491-10MG 04055977183672

      Documentation

      VEGF Inducer, GS4012 - CAS 328073-92-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGF Inducer, GS4012 - CAS 328073-92-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      676491

      References

      Reference overview
      Peterson, R.T., et al. 2004. Nat. Biotechnol. 22, 595.
      Depre, C., et al. 2003. Circulation 108, 2723.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2023 JSW
      Synonyms4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
      DescriptionA cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number328073-92-3
      Chemical formulaC₁₄H₁₅NOS • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml), water, or Methanol (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPeterson, R.T., et al. 2004. Nat. Biotechnol. 22, 595.
      Depre, C., et al. 2003. Circulation 108, 2723.