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616390 Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem

Toxin II, Anemonia sulcata, CAS 60748-45-0, is a toxic polypeptide that specifically activates Na+ channels in excitable membranes. Mixture of isoleucine and valine isomers.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATX II

Primary Target: Na+ channel in excitable membranes
616390
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #
      60748-45-0
      Description
      Overview

      This product has been discontinued.



      Mixture of isoleucine and valine isomers. Highly toxic polypeptide. Acts specifically on Na+ channel in excitable membranes, affecting neuromuscular transmission and mammalian heart muscle function. Augments Na+-dependent increase in twitch response and the duration of action potential. Has a positive inotropic effect on the heart.
      Catalogue Number616390
      Brand Family Calbiochem®
      SynonymsATX II
      References
      ReferencesMantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
      Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
      Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
      Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
      Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
      Alsen, C. 1983. Fed. Proc. 42, 101.
      Product Information
      CAS number60748-45-0
      ATP CompetitiveN
      FormLyophilized solid
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationToxin II, Anemonia sulcata, CAS 60748-45-0, is a toxic polypeptide that specifically activates Na+ channels in excitable membranes. Mixture of isoleucine and valine isomers.
      Biological Information
      Biological activity≤5 µg/kg (tested with shore crabs)
      Primary TargetNa+ channel in excitable membranes
      PurityApproximately 40% ATX II-Ile, 40% ATX II-Val, and 20% other isotoxins by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCK4438200
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616390 0

      Documentation

      Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      616390

      References

      Reference overview
      Mantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
      Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
      Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
      Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
      Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
      Alsen, C. 1983. Fed. Proc. 42, 101.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2009 JSW
      SynonymsATX II
      DescriptionMixture of isoleucine and valine isomers. Highly toxic polypeptide. Acts specifically on the Na+ channel in excitable membranes, affecting neuromuscular transmission and mammalian heart muscle function. Augments the Na+-dependent increase in twitch response and the duration of action potential. Has a positive inotropic effect on the heart.
      FormLyophilized solid
      CAS number60748-45-0
      RTECSCK4438200
      PurityApproximately 40% ATX II-Ile, 40% ATX II-Val, and 20% other isotoxins by HPLC
      Biological activity≤5 µg/kg (tested with shore crabs)
      SolubilityH₂O (2 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C).
      Toxicity Harmful
      ReferencesMantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
      Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
      Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
      Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
      Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
      Alsen, C. 1983. Fed. Proc. 42, 101.