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14-455 Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg

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14-455
650 µg  
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      Overview

      Description
      Catalogue Number14-455
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg
      OverviewA GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD)
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationReagent (Ral GDS-RBD, agarose). A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD), for use in Affinity Binding Assays.
      Key Applications
      • Affinity Binding Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • TERF2IP
      • hRap1
      • DRIP5
      • RAP1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NYB0 # May play a role in telomere length regulation.
      SIZE: 399 amino acids; 44260 Da
      SUBUNIT: Homodimer. Binds to TRF2 (but not TRF1) with its C- terminus.
      SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase and metaphase cells.
      TISSUE SPECIFICITY: Ubiquitous. Highly expressed.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q9NYB0 ## Contains 1 BRCT domain. & Contains 1 Myb-like domain.
      MISCELLANEOUS: Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot analysis
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20C
      Packaging Information
      Material Size650 µg
      Global Trade Item Number
      Catalogue Number GTIN
      14-455 04053252469350