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532757 RIPK2 Inhibitor, OD36 - CAS 1638644-62-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1638644-62-8C₁₆H₁₅ClN₄O₂

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      Glass bottle 5 mg
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      Description
      OverviewA cell permeable, pyrazolopyridine containing macrocycle derivative that acts as a highly potent, selective, ATP-competitive and reversible inhibitor of receptor-interacting protein 2 (RIPK2, IC50 = 5.3 nM). Shown to minimally affect the activity of 366 other protein kinases. At higher concentrations (100 nM), inhibits ALK-2, salt-inducible kinase 2 (SIK2), activin receptor type-2B (ACVR2B), and activin A receptor type II-like 1 (ACVRL1) by ~80%. Blocks RIPK2 autophosphorylation and downstream NF-κB and MAP kinase signaling induced by muramyl dipeptide (MDP), and reduces MDP-induced cellular infiltration of neutrophils and lymphocytes in an in vivo peritonitis model (6.25 mg/kg, i.p.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number532757
      Brand Family Calbiochem®
      SynonymsRIPK2 inhibitor, RIP kinase inhibitor
      References
      ReferencesTigno-Aranjuez, J.T., et al. 2014. J. Biol. Chem. 289, 29651.
      Product Information
      CAS number1638644-62-8
      FormLight beige powder
      Hill FormulaC₁₆H₁₅ClN₄O₂
      Chemical formulaC₁₆H₁₅ClN₄O₂
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetRIPK2
      Primary Target IC<sub>50</sub>5.3 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.32757.0001 04055977281880