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529685 Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem

A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147

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529685
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Overview

Key Spec Table

CAS #Empirical Formula
82-89-3C₂₀H₂₅N₃O

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529685-200UG
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      Description
      OverviewA cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.).
      Catalogue Number529685
      Brand Family Calbiochem®
      SynonymsCasein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147
      References
      ReferencesSchinske, K.A., et al. 2011. Mol. Cancer Ther. 10, 1807.
      Chang, C.C., et al. 2011. J. Biosci. Bioeng. 5, 501
      Ho, T.F., et al. 2009. Toxicol. Appl. Pharmacol. 235, 253
      Soto-Cerrato, V., et al. 2007.Mol. Cancer Ther. 6, 362.
      Product Information
      CAS number82-89-3
      FormDark red solid
      Hill FormulaC₂₀H₂₅N₃O
      Chemical formulaC₂₀H₂₅N₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      529685-200UG 04055977269314