506134 Sigma-AldrichPifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.
More>> A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ
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Overview
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
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| 60477-34-1 | C₁₆H₁₆N₂S · HBr |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor. |
| Catalogue Number | 506134 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ |
| References | |
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| References | Walton, M.I., et al. 2005. Mol. Cancer Ther. 4, 1369. Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14078. |
| Product Information | |
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| CAS number | 60477-34-1 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₆H₁₆N₂S · HBr |
| Chemical formula | C₁₆H₁₆N₂S · HBr |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | PS3 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 506134 | 0 |
Documentation
Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem SDS
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Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 506134 |
References
| Reference overview |
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| Walton, M.I., et al. 2005. Mol. Cancer Ther. 4, 1369. Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14078. |
Brochure
| Title |
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| Caspases and other Apoptosis Related Tools Brochure |
| p53 And Related Products |