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506274
Sigma-AldrichPACOCF₃ - CAS 141022-99-3 - Calbiochem
A novel Ca2+-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).
More>>A novel Ca2+-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM). Less<<
PACOCF₃ - CAS 141022-99-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A novel Ca2+-independent and reversible inhibitor of phospholipase A2 (PLA2; IC50 = 3.8 µM). May also inhibit Ca2+-dependent PLA2 at much higher concentrations (IC50 = 45 µM).
Catalogue Number
506274
Brand Family
Calbiochem®
Synonyms
Palmitoyl Trifluoromethyl Ketone
References
References
Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519. Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55. Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.
3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.
Purity
≥97% by TLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
-20°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
PACOCF₃ - CAS 141022-99-3 - Calbiochem Certificates of Analysis
Title
Lot Number
506274
References
Reference overview
Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519. Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55. Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
15-April-2011 RFH
Synonyms
Palmitoyl Trifluoromethyl Ketone
Description
A novel Ca2+-independent phospholipase A2 inhibitor (IC50 = 3.8 µM). May also inhibit Ca2+-dependent phospholipase A2 at higher concentrations (IC50 = 45 µM)
Form
Liquid
Formulation
In ethanol.
CAS number
141022-99-3
Chemical formula
C₁₇H₃₁F₃O
Structure formula
Purity
≥97% by TLC
Solubility
Supplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
Toxicity
Standard Handling
References
Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519. Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55. Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.
