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SCC180 OECM-1 Human Oral Squamous Carcinoma Cell Line

OECM-1 human oral squamous carcinoma cell line is suitable for studies of cancer cell signaling, epithelial-mesenchymal transition (EMT), metastasis, invasion, and cancer cell stemness.

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SCC180
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC180
      DescriptionOECM-1 Human Oral Squamous Carcinoma Cell Line
      OverviewThe OECM-1 human oral cavity squamous cell carcinoma cell line is a well-established model for squamous cell carcinoma. The OECM-1 cell line harbors a missense mutation in the p53 tumor suppressor (2), displays low EGFR expression (3), and is tumorigenic in nude mice (4). OECM-1 cells proliferate with a doubling time of 30-38 hours and are capable of anchorage-independent growth, forming spheroid colonies (4). OECM-1 cells have been intensively characterized in the literature for morphology, biomarker expression and drug response (5,6).

      Source:
      The OECM-1 human oral cavity squamous cell carcinoma cell line was derived from surgical resection of a primary tumor of a Taiwanese male patient (4).
      Alternate Names
      • OECM1
      • OEC-M1
      Background InformationSquamous cell carcinoma (SCC) is a common cancer type, developing in epithelial cells. Nearly all cancers of the oral cavity are squamous cell carcinomas, and the high recurrence rate among oral SCCs make these challenging targets for therapies. Established models of this cancer type continue to yield significant insights into the properties and potential treatments of head and neck cancers (1).

      References:
      1. Méry B et al., (2017) Oral Oncol 65: 51-56.
      2. Lin SC et al., (2004) J Oral Pathol Med 33(2): 79-86.
      3. Lee CH, Hung HW, Hung PH, Shieh YS (2010) Mol Cancer 9:64.
      4. Yang CY, Meng CL (1994) J Dent Res 73(8): 1407-1415.
      5. Huang GC, Liu SY, Lin MH, Kuo YY, Liu YC (2004) Jpn J Clin Oncol 34(9): 499-504.
      6. Meng CL, Yang CY, Shen KL, Wong PY, Lee HK (1998) Arch Oral Biol 43(12): 979-986.
      7. Chang CW et al., (2018) Cell Death Dis 9(2): 194.
      References
      Product Information
      Applications
      ApplicationOECM-1 human oral squamous carcinoma cell line is suitable for studies of cancer cell signaling, epithelial-mesenchymal transition (EMT), metastasis, invasion, and cancer cell stemness.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsOECM-1 human oral cavity squamous carcinoma cell line should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC180 04054839713989