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532336 NOX Inhibitor VIII, VAS3947 - CAS 869853-70-3 - Calbiochem

VAS3947, NOXi

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947

Primary Target: NADPH Oxidase
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532336
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Overview

Key Spec Table

CAS #Empirical Formula
869853-70-3C₁₄H₁₀N₆OS

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable triazolo-pyrimidine derivative of VAS2870 (Cat. No. 492000) that displays enhanced solubility and acts as a selective inhibitor NOX family of NADPH oxidase. Shown to inhibit NOX activity in CaCo-2 cells (expressing NOX 1, 2, 4, and 5; IC50 = 12 µM), HL-60 cells (mainly expressing NOX2; IC50 = 2 µM), and A7r5 cells (mainly expressing NOX3 and 4; IC50 = 13 µM). Does not affect the activities of xanthine oxidase and endothelial nitric oxide synthase (eNOS) even at higher concentrations (~100 µM). Acts synergistically with Imatinib (Cat. No. 504595) to reduce the proliferation of chronic myeloid leukemia (CML) cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532336
      Brand Family Calbiochem®
      Synonyms3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947
      References
      ReferencesSanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014.
      Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327.
      Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885.
      Product Information
      CAS number869853-70-3
      FormLight yellow solid
      Hill FormulaC₁₄H₁₀N₆OS
      Chemical formulaC₁₄H₁₀N₆OS
      Quality LevelMQ100
      Biological Information
      Primary TargetNADPH Oxidase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.32336.0001 04055977260069