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475895 Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      22373-78-0C₃₆H₆₁O₁₁ . Na
      Description
      OverviewPolyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.
      Catalogue Number475895
      Brand Family Calbiochem®
      References
      ReferencesInabayashi, M., et al. 1995. Biochemistry 34, 3455.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
      Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
      Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
      Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
      Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
      Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.
      Product Information
      CAS number22373-78-0
      ATP CompetitiveN
      FormOff-white to beige solid
      Hill FormulaC₃₆H₆₁O₁₁ . Na
      Chemical formulaC₃₆H₆₁O₁₁ . Na
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFunctions as a Na+ ionophore
      Purity≥97% by Assay
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJH2830000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475895 0

      Documentation

      Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      475895

      References

      Reference overview
      Inabayashi, M., et al. 1995. Biochemistry 34, 3455.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
      Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
      Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
      Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
      Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
      Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-January-2011 JSW
      DescriptionPolyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.
      FormOff-white to beige solid
      CAS number22373-78-0
      RTECSJH2830000
      Chemical formulaC₃₆H₆₁O₁₁ . Na
      Structure formulaStructure formula
      Purity≥97% by Assay
      SolubilityChloroform, Ethanol, or Methanol
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.
      Toxicity Highly Toxic
      Merck USA index14, 6246
      ReferencesInabayashi, M., et al. 1995. Biochemistry 34, 3455.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
      Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
      Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
      Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
      Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
      Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.

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      Categories

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