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420116 JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem

JNK Inhibitor I, (L)-Form, Cell-Permeable peptide with a C-terminal sequence from the JNK-binding domain and an N-terminal peptide with HIV-TAT48-57 sequence. Blocks c-jun activation (IC50&n

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Synonyms: (L)-JNKI1, (L)-HIV-TAT₄₈₋₅₇-PP-JBD₂₀, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂, c-Jun NH₂-terminal kinase, SAPK Inhibitor I

Primary Target: JNK
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420116
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Overview

Key Spec Table

Empirical Formula
C₁₆₈H₂₉₃N₆₇O₄₂

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420116-1MG
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      Description
      OverviewA cell-permeable, biologically active peptide consisting of a carboxyl terminal sequence derived from the JNK-binding domain (JBD) and an amino terminal peptide containing the HIV-TAT48-57 sequence. Blocks c-Jun NH2-terminal kinase (JNK) signaling by preventing the activation of the transcription factor c-jun (IC50 ~ 1 µM). This effect appears to be due to inhibition of phosphorylation of the activation domains of JNK. Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB) that is shown to be critical for interaction with JNK linked to the 10-amino acid HIV-TAT48-57 sequence as a carrier peptide and two proline residues as spacer. Inhibits IL-1β-induced c-jun and c-fos expression in insulin secreting βTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no effect on either ERK 1/2 or p38 activities.
      Catalogue Number420116
      Brand Family Calbiochem®
      Synonyms(L)-JNKI1, (L)-HIV-TAT₄₈₋₅₇-PP-JBD₂₀, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂, c-Jun NH₂-terminal kinase, SAPK Inhibitor I
      References
      ReferencesBarr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Bonny, C., et al. 2001. Diabetes 50, 77.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patents 6,043,083 and 6,410,693.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₆₈H₂₉₃N₆₇O₄₂
      Chemical formulaC₁₆₈H₂₉₃N₆₇O₄₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationJNK Inhibitor I, (L)-Form, Cell-Permeable peptide with a C-terminal sequence from the JNK-binding domain and an N-terminal peptide with HIV-TAT48-57 sequence. Blocks c-jun activation (IC50 ~ 1 µM).
      Biological Information
      Primary TargetJNK
      Primary Target IC<sub>50</sub>1 µM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Gly-Arg-Lys-Lys-Arg-Agr-Gln-Arg-Arg-Arg-Pro-Pro-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-Pro-Gln-Val-Pro-Arg-Ser-Gln-Asp-Thr-NH₂
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420116-1MG 04055977187946