Millipore Sigma Vibrant Logo

420097 InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Primary Target: murine JAK1
View Products on Sigmaaldrich.com
420097
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
457081-03-7C₁₈H₁₆FN₃O

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
420097-500UG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 500 μg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      Catalogue Number420097
      Brand Family Calbiochem®
      Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
      References
      ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
      Product Information
      CAS number457081-03-7
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
      Hill FormulaC₁₈H₁₆FN₃O
      Chemical formulaC₁₈H₁₆FN₃O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
      Biological Information
      Primary Targetmurine JAK1
      Primary Target IC<sub>50</sub>15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
      Primary Target K<sub>i</sub> 5 nM against JAK3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420097-500UG 04055977187861