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239806 InSolution™ Cyclopamine, V. californicum - Calbiochem

The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Shh Signaling Antagonist I in EtOH

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239806
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₇H₄₁NO₂

Pricing & Availability

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239806-5MG
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      		 Glass bottle 5 mg
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      Description
      OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
      Catalogue Number239806
      Brand Family Calbiochem®
      SynonymsShh Signaling Antagonist I in EtOH
      References
      ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
      Thayer, S.P., et al. 2003. Nature, 425, 851.
      Watkins, D.N., et al. 2003. Nature 422, 313.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Berman, D.M., et al. 2002. Science 297, 1559.
      Taipale, J., et al. 2000. Nature 406, 1005.
      Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.
      Product Information
      FormLiquid
      FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
      Hill FormulaC₂₇H₄₁NO₂
      Chemical formulaC₂₇H₄₁NO₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 10

      Flammable.
      S PhraseS: 16-7

      Keep away from sources of ignition - No Smoking.
      Keep container tightly closed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      239806-5MG 04055977198911

      Documentation

      InSolution™ Cyclopamine, V. californicum - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Cyclopamine, V. californicum - Calbiochem Certificates of Analysis

      TitleLot Number
      239806

      References

      Reference overview
      Berman, D.M., et al. 2003. Nature, 425, 846.
      Thayer, S.P., et al. 2003. Nature, 425, 851.
      Watkins, D.N., et al. 2003. Nature 422, 313.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Berman, D.M., et al. 2002. Science 297, 1559.
      Taipale, J., et al. 2000. Nature 406, 1005.
      Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-June-2012 JSW
      SynonymsShh Signaling Antagonist I in EtOH
      DescriptionA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
      FormLiquid
      FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₇H₄₁NO₂
      Structure formulaStructure formula
      Purity≥97% by NMR
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
      Thayer, S.P., et al. 2003. Nature, 425, 851.
      Watkins, D.N., et al. 2003. Nature 422, 313.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Berman, D.M., et al. 2002. Science 297, 1559.
      Taipale, J., et al. 2000. Nature 406, 1005.
      Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.