Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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Description
Catalogue Number
658411
Brand Family
Calbiochem®
Synonyms
JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
References
References
Jaleel, M., et al. 2004. Biochemistry43, 8247. Eriksen, K.W., et al. 2001. Leukemia15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem.34, 1896. Levitzki, A. 1990. Biochem. Pharmacol.40, 913.
Product Information
Form
Liquid
Formulation
A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Irritant
Storage
≤ -70°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
InSolution™ AG490 - Calbiochem Certificates of Analysis
Title
Lot Number
658411
References
Reference overview
Jaleel, M., et al. 2004. Biochemistry43, 8247. Eriksen, K.W., et al. 2001. Leukemia15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem.34, 1896. Levitzki, A. 1990. Biochem. Pharmacol.40, 913.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
20-November-2008 JSW
Synonyms
JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
Description
Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
Form
Liquid
Formulation
A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₇H₁₄N₂O₃
Structure formula
Purity
≥98% by HPLC
Storage
Protect from light ≤ -70°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
Toxicity
Irritant
References
Jaleel, M., et al. 2004. Biochemistry43, 8247. Eriksen, K.W., et al. 2001. Leukemia15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem.34, 1896. Levitzki, A. 1990. Biochem. Pharmacol.40, 913.