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385920 HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol

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385920
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
171009-07-7C₂₀H₂₀N₂O₄

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      Description
      OverviewA cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
      Catalogue Number385920
      Brand Family Calbiochem®
      Synonyms4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
      References
      ReferencesHardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
      Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
      Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
      Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
      Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.
      Product Information
      CAS number171009-07-7
      FormWhite solid
      Hill FormulaC₂₀H₂₀N₂O₄
      Chemical formulaC₂₀H₂₀N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 24/25-36/37/39

      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      385920-5MG 04055977189841

      Documentation

      HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      385920

      References

      Reference overview
      Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
      Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
      Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
      Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
      Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-March-2008 JSW
      Synonyms4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
      DescriptionA cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171009-07-7
      Chemical formulaC₂₀H₂₀N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (35 mg/ml), H₂O (1.7 mg/ml) or Ethanol (35 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesHardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
      Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
      Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
      Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
      Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.