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371721 GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem

The GPR40 Agonist II controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II

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371721
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1206629-08-4C₁₆H₁₁Cl₂NO₂

Pricing & Availability

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371721-10MG
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      Description
      OverviewA cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical and metabolic stability.
      Catalogue Number371721
      Brand Family Calbiochem®
      Synonyms3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II
      References
      ReferencesChristiansen, E., et al. 2011, J. Med. Chem. 54, 6691.
      Product Information
      CAS number1206629-08-4
      FormOff-white powder
      Hill FormulaC₁₆H₁₁Cl₂NO₂
      Chemical formulaC₁₆H₁₁Cl₂NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      371721-10MG 04055977213249

      Documentation

      GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GPR40 Agonist II - CAS 1206629-08-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      371721

      References

      Reference overview
      Christiansen, E., et al. 2011, J. Med. Chem. 54, 6691.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2012 JSW
      Synonyms3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II
      DescriptionA cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical (0.1% degradation after 12 days in PBS at 37 °C) and metabolic (3% metabolization by human liver S9 stability test) stability.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1206629-08-4
      Chemical formulaC₁₆H₁₁Cl₂NO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
      Toxicity Standard Handling
      ReferencesChristiansen, E., et al. 2011, J. Med. Chem. 54, 6691.