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344281 Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskol

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Synonyms: 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl

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344281
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Overview

Key Spec Table

CAS #Empirical Formula
138605-00-2C₂₇H₄₃NO₈ • HCl

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      Description
      OverviewA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
      Catalogue Number344281
      Brand Family Calbiochem®
      Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
      References
      ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
      Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
      Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
      Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
      Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
      Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
      Shafiq, J., et al. 1992. Circ. Res. 71, 70.
      Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
      Product Information
      CAS number138605-00-2
      FormWhite solid
      Hill FormulaC₂₇H₄₃NO₈ • HCl
      Chemical formulaC₂₇H₄₃NO₈ • HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 26/27/28-62-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344281-5MG 04055977214673