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509374 Fn14 Antagonist, L524-0366 - CAS 951612-19-4 - Calbiochem

Specifically binds to the Fn14 surface (Kd = 7.12 mM) and suppresses TWEAK-induced glioma cell migration.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fibroblast Growth Factor-inducible 14 Antagonist; L5240366, THD Receptor Antagonist; TNF-like Weak Inducer of Apoptosis Receptor Antagonist, TWEAK Receptor Antagonist; TWEAK-Fn14 Interaction Inhibitor

Primary Target: fibroblast growth factor-inducible 14 (Fn14)
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509374
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Overview

Key Spec Table

CAS #Empirical Formula
951612-19-4C₁₃H₁₃ClN₄OS

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      		 Glass bottle 10 mg
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      Description
      OverviewA triazolyl-thiomorpholinyl-methanone compound that competes against TWEAK C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). Shown to completely inhibit 100 ng/mL sTWEAK-stimulated migration of T98G glioma cells at 10 µM concentration and is more potent against sTWEAK- than TNFα-induced NF-κB activation (IC50 = 7.8 vs. 31.03 µM, respectively, in reporter assays) without any apparent cytotoxicity up to 50 µM and 72 h in T98G cultures.
      Catalogue Number509374
      Brand Family Calbiochem®
      SynonymsFibroblast Growth Factor-inducible 14 Antagonist; L5240366, THD Receptor Antagonist; TNF-like Weak Inducer of Apoptosis Receptor Antagonist, TWEAK Receptor Antagonist; TWEAK-Fn14 Interaction Inhibitor
      References
      ReferencesDhruv, H., et al. 2013. J. Biol. Chem. 288, 32261.
      Product Information
      CAS number951612-19-4
      FormWhite powder
      Hill FormulaC₁₃H₁₃ClN₄OS
      Chemical formulaC₁₃H₁₃ClN₄OS
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target fibroblast growth factor-inducible 14 (Fn14)
      Primary Target K<sub>i</sub>7.12 µ
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.09374.0001 04055977241839