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14-610M Flt-3 (D835Y) Protein, active, 250 µg

Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.

Flt-3 (D835Y) Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-610M
250 µg  Also available in 10 μg size (cat#14-610) and in bulk (cat# 14-610-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-610M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFlt-3 (D835Y) Protein, active, 250 µg
      OverviewN-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
      Gene Symbol
      • FLT3
      • STK-1
      • FLK2
      • CD135
      • OTTHUMP00000042340
      • STK1
      Protein TargetFlt3
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
      SIZE: 993 amino acids; 112903 Da
      SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Bone marrow cells.
      SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.
      Molecular Weight77.4kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of 50μM Abltide (Catalog # 12-493)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-610) and in bulk (cat# 14-610-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-610M 04053252508783