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14-583M FGFR4 Protein, active, 250 µg

Active, N-terminal, His6-tagged, recombinant, human FGFR4 amino acids 442-755, for use in Kinase Assays.

FGFR4 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-583M
250 µg  Also available in 10 μg size (cat#14-583) and in bulk (cat# 14-583-K).
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      Overview

      Description
      Catalogue Number14-583M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFGFR4 Protein, active, 250 µg
      OverviewN-terminal, His6-tagged, recombinant, human FGFR4 amino acids 442-755
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal, His6-tagged, recombinant, human FGFR4 amino acids 442-755, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
      Gene Symbol
      • FGFR4
      • TKF
      • FGFR-4
      • MGC20292
      • CD334
      • JTK2
      Protein TargetFGFR4
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22455 # Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
      SIZE: 802 amino acids; 87954 Da
      SUBUNIT: Interacts with KLB (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P22455 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight36.4kDa
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-583) and in bulk (cat# 14-583-K).
      Global Trade Item Number
      Catalogue Number GTIN
      14-583M 04053252478277