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341205 Etoposide - CAS 33419-42-0 - Calbiochem

Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.

Etoposide - CAS 33419-42-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: VP-16

Primary Target: topoisomerase 2
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341205
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Overview

Key Spec Table

CAS #Empirical Formula
33419-42-0C₂₉H₃₂O₁₃

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341205-25MG
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      Description
      OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
      Catalogue Number341205
      Brand Family Calbiochem®
      SynonymsVP-16
      References
      ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
      Product Information
      CAS number33419-42-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₃₂O₁₃
      Chemical formulaC₂₉H₃₂O₁₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
      Biological Information
      Primary Targettopoisomerase 2
      Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSKC0190000
      Safety Information
      R PhraseR: 22-45

      Harmful if swallowed.
      May cause cancer.
      S PhraseS: 26-36/37/39-45-53

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      341205-25MG 04055977215434