Millipore Sigma Vibrant Logo

05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action
View Products on Sigmaaldrich.com
05-23-3800
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
05-23-3800-0.1MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule .1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      05-23-3800-0.5MG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic ampoule .5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          05-23-3800-1MG
          Retrieving availability...
          —
          Limited Availability Limited Availability
          In Stock 
          Discontinued
          Limited Quantities Available
          Availability to be confirmed
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              		 Plastic ampoule 1 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity is a multiple of
              Maximum Quantity is
              Upon Order Completion More Information
              You Saved ()
               
              —
              Request Pricing
              		 —
              Description
              OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
              Catalogue Number05-23-3800
              Brand Family Calbiochem®
              SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
              References
              ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
              Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
              Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
              Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
              Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
              Yanagisawa, M., et al. 1988. Nature 332, 411.
              Product Information
              CAS number117399-94-7
              ATP CompetitiveN
              FormWhite to off-white solid
              FormulationSupplied as an acetate salt.
              Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
              Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
              ReversibleN
              Sold on the basis of peptide contentY
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetPotent vasoconstrictive action
              Purity≥96% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              05-23-3800-0.1MG 04055977226775
              05-23-3800-0.5MG 04055977226782
              05-23-3800-1MG 04055977226799

              Documentation

              Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem Certificates of Analysis

              TitleLot Number
              05-23-3800

              References

              Reference overview
              Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
              Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
              Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
              Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
              Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
              Yanagisawa, M., et al. 1988. Nature 332, 411.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision12-May-2008 JSW
              SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
              DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
              FormWhite to off-white solid
              FormulationSupplied as an acetate salt.
              CAS number117399-94-7
              Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
              Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
              Purity≥96% by HPLC
              Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
              Storage Protect from moisture
              -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
              Toxicity Standard Handling
              ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
              Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
              Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
              Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
              Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
              Yanagisawa, M., et al. 1988. Nature 332, 411.