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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine

Primary Target: PI-PLC
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341207
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

Pricing & Availability

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341207-50MG
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      341207-5MG
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      Limited Availability Limited Availability
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          Description
          OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
          Catalogue Number341207
          Brand Family Calbiochem®
          SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          References
          ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Product Information
          CAS number70641-51-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₇H₅₈NO₆P
          Chemical formulaC₂₇H₅₈NO₆P
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPI-PLC
          Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYK0718000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          341207-50MG 04053252041402
          341207-5MG 04055977215441

          Documentation

          ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          341207

          References

          Reference overview
          Harguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.

          Posters

          Title
          Human Kinome & InhibitorSelect™ Libraries
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-May-2011 JSW
          SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          DescriptionA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
          FormWhite solid
          CAS number70641-51-9
          RTECSYK0718000
          Chemical formulaC₂₇H₅₈NO₆P
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Toxicity Carcinogenic / Teratogenic
          ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.