219494 Sigma-AldrichCdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem
The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephos
More>> The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(3-(2-pyridyl)phenylamino)-9-isopropylpurine, hydrate
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1186647-87-9 | C₂₃H₂₇N₇O • H₂O |
| Description | |
|---|---|
| Overview | A cell-permeable ATP-binding pocket-targeting (R)-Roscovitine (Cat. Nos. 550360 & 550364) derivative that is more potent than Roscovitine in inhibiting CDK1,CDK5, and CK1 activity (IC50 = 220,80,14 vs. 350, 200, 2300 nM, respectively), while maintaining selectivity against GSK-3α/β (IC50 = 4.1 µM). The CDK/CK1 dual-specificity nature of (R)-DRF053 most likely accounts for its superior activity to that of (R)-Roscovitine against β40 production from APP-expressing N2A cells (90% vs. 50% inhibition wtih 100 µM respective compound). |
| Catalogue Number | 219494 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(3-(2-pyridyl)phenylamino)-9-isopropylpurine, hydrate |
| References | |
|---|---|
| References | Oumata, N., et al. J. Med. Chem. 51, 5229. Bettayeb, K., et al. 2008. Oncogene 27, 5797. |
| Product Information | |
|---|---|
| CAS number | 1186647-87-9 |
| Form | Pale yellow solid |
| Hill Formula | C₂₃H₂₇N₇O • H₂O |
| Chemical formula | C₂₃H₂₇N₇O • H₂O |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 219494 | 0 |