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217694 Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

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Synonyms: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

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217694
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Overview

Key Spec Table

CAS #Empirical Formula
93718-83-3C₁₄H₁₄O₄S₂

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217694-10MG
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      Description
      OverviewA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
      Catalogue Number217694
      Brand Family Calbiochem®
      Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
      References
      ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
      Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
      Product Information
      CAS number93718-83-3
      FormOrange solid
      Hill FormulaC₁₄H₁₄O₄S₂
      Chemical formulaC₁₄H₁₄O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      217694-10MG 04055977202304