219012 Sigma-AldrichCaspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 745046-84-8 | C₂₀H₂₁N₃O₇S |
| Description | |
|---|---|
| Overview | This product has been discontinued. A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells. |
| Catalogue Number | 219012 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
| References | |
|---|---|
| References | Kravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680. |
| Product Information | |
|---|---|
| CAS number | 745046-84-8 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₂₀H₂₁N₃O₇S |
| Chemical formula | C₂₀H₂₁N₃O₇S |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | capase-3 |
| Primary Target IC<sub>50</sub> | 23 nM |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 219012 | 0 |