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14-458 CSK Protein, active, 10 µg

Active, recombinant full-length human CSK, containing an N-terminal GST-tag incorporating a PreScission Protease cleavage site, for use in Kinase Assays.

CSK Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-458
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-458M when ordering the 250 µg size.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-458
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCSK Protein, active, 10 µg
      OverviewRecombinant full-length human CSK, containing an N-terminal GST-tag incorporating a PreScission Protease cleavage site
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, recombinant full-length human CSK, containing an N-terminal GST-tag incorporating a PreScission Protease cleavage site, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed in E. coli BL21 (DE3) cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • CSK
      • MGC117393
      Protein TargetCSK
      Purification MethodGSH-agarose chromatography
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41240 # Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
      SIZE: 450 amino acids; 50704 Da
      SUBUNIT: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also present in lipid rafts (By similarity).
      TISSUE SPECIFICITY: Expressed in lung and macrophages.
      PTM: Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
      SIMILARITY: SwissProt: P41240 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight77.6kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of Poly (Glu4Tyr) substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-458M when ordering the 250 µg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-458 04053252410734

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-458M CSK Protein, active, 250 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases