Millipore Sigma Vibrant Logo

205531 CA-074 Me - Calbiochem

CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.

CA-074 Me - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester

Primary Target: cathepsin B
View Products on Sigmaaldrich.com
205531
View Pricing & Availability

Overview

Key Spec Table

Empirical Formula
C₁₉H₃₁N₃O₆

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
205531-1MG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 1 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
      Catalogue Number205531
      Brand Family Calbiochem®
      SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
      References
      ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
      Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
      Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
      Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₉H₃₁N₃O₆
      Chemical formulaC₁₉H₃₁N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      205531-1MG 07790788048433