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203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem

An enhanced water-soluble form of Bisindolylmaleimide I.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl

Primary Target: Protein kinase C
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203291
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Overview

Key Spec Table

CAS #Empirical Formula
176504-36-2C₂₅H₂₄N₄O₂ · HCl

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      Description
      OverviewAn enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
      Catalogue Number203291
      Brand Family Calbiochem®
      Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
      References
      ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
      Kuchera, S., et al. 1993. Agents Actions 39, C169.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Product Information
      CAS number176504-36-2
      ATP CompetitiveY
      FormOrange-red solid
      Hill FormulaC₂₅H₂₄N₄O₂ · HCl
      Chemical formulaC₂₅H₂₄N₄O₂ · HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetProtein kinase C
      Primary Target K<sub>i</sub>10 nM against protein kinase C
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      203291-1MG 04055977221152