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SCC256 BPH-1 Human Benign Prostatic Hyperplasia Cell Line

The BPH-1 cell line is a well-established model for human prostate biology and widely used for investigation into the causes and potential treatments for prostatic disease.

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SCC256
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC256
      DescriptionBPH-1 Human Benign Prostatic Hyperplasia Cell Line
      Alternate Names
      • BPH1
      Background InformationBPH-1 is an immortalized benign prostatic hyperplasia cell line that is a highly cited human model for prostate growth and physiology. Compared to prostate cancer cell lines, BPH-1 cells expressed increased levels of estradiol (E2) and aromatase, factors that have been implicated in BPH progression (2). BPH-1 cells share the cytokeratin profile of luminal epithelial cells and do not express androgen receptor or prostate-specific antigen (PSA) (3). BPH-1 cells express the proto-oncogene p53 and harbor several chromosomal structural rearrangements but are non-tumorigenic in nude mice (3).

      Source:
      The BPH-1 cell line was established from primary prostatic tissue from a 68-year-old patient and the cell line was immortalized with Simian virus 40 (SV40) large T antigen (3). BPH-1 cells contain a neomycin resistance cassette and are resistant to G418.

      References:
      1. Asian J Urol. 2017; 4(3): 148-161.
      2. J Endocrinol. 2007; 195(1): 89-94.
      3. In Vitro Cell Dev Biol Anim. 1995; 31(1): 14-24.
      References
      Product Information
      HS Code3002 90 99
      Applications
      ApplicationThe BPH-1 cell line is a well-established model for human prostate biology and widely used for investigation into the causes and potential treatments for prostatic disease.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Epithelial Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC256 04061841079835