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MABS481 Anti-PL Scramblase 3, clone 3B4 Antibody

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MABS481
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS481
      DescriptionAnti-PL Scramblase 3, clone 3B4 Antibody
      Alternate Names
      • Phospholipid scramblase 3
      • PL scramblase 3
      • Ca(2+)-dependent phospholipid scramblase 3
      Background InformationPhospholipid scramblase 3 (PL scramblase 3), also known as Ca(2+)-dependent phospholipid scramblase 3, and encoded by the gene name PLSCR3, is a member of the phospholipid scramblase family. Recent studies have indicated that PL scramblase 3 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PL scramblase 3 is suggested to play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It may also play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. PL scramblase 3 has been demonstrated to interact with PDCD6 in a calcium-dependent manner.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-PL Scramblase 3 antibody is validated for use in Western Blotting for the detection of PL Scramblase 3.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected PL Scramlase 3 in SH-SY5Y cell lysate (Chu, C.T., et al. (2013). Nature Cell Biology. 15(10):1197-1205).
      Western Blotting Analysis: A representative lot detected PL Scramlase 3 in primary adipocytes lysate (Wiedmer, T., et al. (2004). PNAS. 101(36):13296-13301).
      Biological Information
      ImmunogenRecombinant protein corresponding to human PL Scramlase 3.
      Clone3B4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Plscr3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~31 kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in NIH-3T3/L1 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected PL Scramlase 3 in 10 µg of NIH-3T3/L1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MABS481 04055977121636