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AB10440 Anti-PACSIN3 Antibody, NT

Anti-PACSIN3 Antibody, N-terminus is an antibody against PACSIN3 for use in WB, IH(P).

Research Category: Cell Structure Research Sub-Category: Cytoskeletal Signaling Gene Symbol: SDPIII UniProt Number: Q9UKS6
AB10440
100 µg   
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10440
      DescriptionAnti-PACSIN3 Antibody, NT
      Alternate Names
      • Endophilin I
      • SH3 domain-containing protein 6511
      • protein kinase C and casein kinase substrate in neurons 3
      • syndapin III
      Background InformationPACSINs are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN3 (protein kinase C and casein kinase substrate in neurons 3) contains a short proline-rich region and lacks asparagine-proline-phenylalanine motifs, that differentiates it from the rest of the PACSIN family. Expected molcular weight is 49 kDa.
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain lysate
      PresentationPBS containing 0.09% NaN3.
      Applications
      ApplicationAnti-PACSIN3 Antibody, N-terminus is an antibody against PACSIN3 for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN3.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe antibody recognizes human and mouse PACSIN3.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman and mouse. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SDPIII
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role in vesicle formation and transport.
      SUBUNIT STRUCTURE: Homo- and hetero-aggregates with other PACSINs. Binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Also interacts with MDC9 and MDC15 By similarity.
      SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note= Detected at the inner aspect of the plasma membrane in cells or myotubes.
      TISSUE SPECIFICTY: Expressed in heart and skeletal muscle, lung, kidney, adrenal gland and placenta.
      PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.
      SEQUENCE SIMILARITIES: Belongs to the PACSIN family.
      Contains 1 FCH domain.
      Contains 1 SH3 domain.
      Molecular Weight~53 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Western blot on mouse brain lysate using 1:250 dilution of Anti-PACSIN3.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10440 04053252743740

      Documentation