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MAB5216 Anti-NMDAR2A Antibody

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MAB5216
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), ICC, IHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB5216
      ReplacesMAB5218
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2A Antibody
      Alternate Names
      • NR2A
      Product Information
      FormatPurified
      PresentationAffinity purified immunoglobulin. Liquid in PBS. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NMDAR2A Antibody detects level of NMDAR2A & has been published & validated for use in IH(P), IC, IH & WB.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry (light and EM) on 4% paraformaldehyde & 0.125% glutaraldehyde fixed tissue: 2.5-5 μg/mL.

      Immunocytochemistry: 2.5-5.0μg/mL

      Western blot: 1-5 μg/mL Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAmino acid region 1099-1213 from human NMDAR2A produced as a GST fusion protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAmino acid region 1099-1213 from human NMDAR2A produced as a GST fusion protein.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
      Gene Symbol
      • GRIN2A
      • hNR2A
      • Glutamate
      • NMDAR2A
      • NR2A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12879 # NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
      SIZE: 1464 amino acids; 165283 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: Q12879 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5216 04053252662195