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MABE913 Anti-Ikaros Antibody, clone Ik14

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MABE913
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ChIP, ChIP-seqMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE913
      DescriptionAnti-Ikaros Antibody, clone Ik14
      Alternate Names
      • DNA-binding protein Ikaros
      • Ikaros family zinc finger protein 1
      • Lymphoid transcription factor LyF-1
      Background InformationIkaros, also known as IKZF1, is a transcription factor that is important for the regulation of lymphopoiesis and also the development of the immune system. It has also been linked to adult and fetal erythroid differentiation in humans. Ikaros has been shown to induce local chromatin accessibility during CD4+ T cell differentiation and therefore, activating Th2 expression.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ikaros, clone Ik14 is an antibody against Ikaros for use in WB, ChIP, ChIP-seq.
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      • ChIP-seq
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected Ikaros in 10 µg of HL-60 and human lymph node lysate.
      Chromatin Immunoprecipitation (ChIP): A representative lot of this antibody as part of a blend Ikaros clones Ik14 and E9 (catalogue numbers MABE913 and MABE912 respectively) was demonstrated to perform in ChIP. See Zhang et al. (2012).
      ChIP-seq Analsysis: A representative lot of this antibody as part of a blend Ikaros clones E9 and Ik14 (catalogue number MABE912 and MABE913 respectively) was demonstrated to perform in ChIP-seq. See Zhang et al. (2012).
      Biological Information
      ImmunogenRecombinant protein corresponding to Human Ikaros.
      CloneIk14
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IKZF1
      • IK1
      • IKAROS
      • LYF1
      • ZNFN1A1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in a Jurkat cell lysate.

      Western Blotting Analysis: A 0.5 µg/mL dilution of this antibody detected Ikaros in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MABE913 04055977112689