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AB2043 Anti-Elastin Antibody

Detect Elastin using this Anti-Elastin Antibody validated for use in ELISA, RIA, IH.

Anti-Elastin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ELN, tropoelastin, FLJ38671, SVAS, WS, Tropoelastin, elastin, FLJ43523, WBS UniProt Number: P15502
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AB2043
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, RIA, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2043
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Elastin Antibody
      References
      Product Information
      FormatPurified
      Control
      • Control tissue: human skin or liver
      PresentationThe purified antibody is supplied in a buffer containing a mixture of 0.1M Citrate, 0.1M potassium phosphate, at a pH of 7.2-7.4 and 10µl/ml of antibiotics and antimycotics.
      Quality LevelMQ100
      Applications
      ApplicationDetect Elastin using this Anti-Elastin Antibody validated for use in ELISA, RIA, IH.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen human skin and liver tissues.

      Radioimmunoassay

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenElastin extracted and purified from human skin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody shows less than 0.1% reactivity with human Collagen I, II, III, IV, V and human Fibronectin as well as Rat Elastin by radioimmunoassay.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • ELN
      • tropoelastin
      • FLJ38671
      • SVAS
      • WS
      • Tropoelastin
      • elastin
      • FLJ43523
      • WBS
      Non-Reactive Species
      • Rat
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15502 # Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
      SIZE: 786 amino acids; 68499 Da
      SUBUNIT: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.
      TISSUE SPECIFICITY: Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.
      PTM: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. & Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4- hydroxylation in vertebrates (By similarity).
      DISEASE: SwissProt: P15502 # Defects in ELN are a cause of autosomal dominant cutis laxa [MIM:123700]. Cutis laxa is a rare connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. The skin changes are often accompanied by extracutaneous manifestations, including pulmonary emphysema, bladder diverticula, pulmonary artery stenosis and pyloric stenosis. & Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder and a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. & Defects in ELN are the cause of supravalvular aortic stenosis (SVAS) [MIM:185500]. SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome.
      SIMILARITY: SwissProt: P15502 ## Belongs to the elastin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2043 04053252325274

      Documentation

      Anti-Elastin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Elastin Antibody Certificates of Analysis

      TitleLot Number
      ANTI-ELASTIN ANTIBODY - 3933316 3933316
      ANTI-ELASTIN ANTIBODY - 4025978 4025978
      ANTI-ELASTIN ANTIBODY - 4127483 4127483
      RABBIT ANTI-HUMAN ELASTIN POLYCLONAL ANTIBODY - 2361784 2361784
      RABBIT ANTI-HUMAN ELASTIN - 3239904 3239904
      RABBIT ANTI-HUMAN ELASTIN - 3257093 3257093
      RABBIT ANTI-HUMAN ELASTIN - 3446400 3446400
      RABBIT ANTI-HUMAN ELASTIN - 3517613 3517613
      RABBIT ANTI-HUMAN ELASTIN - 3528152 3528152
      RABBIT ANTI-HUMAN ELASTIN - 3593178 3593178
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies