Millipore Sigma Vibrant Logo

410957 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IBMX

Primary Target: cAMP and cGMP phosphodiesterases
View Products on Sigmaaldrich.com
410957
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
28822-58-4C₁₀H₁₄N₄O₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
410957-1GM
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 1 gm
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      410957-250MG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic ampoule 250 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
          Catalogue Number410957
          Brand Family Calbiochem®
          SynonymsIBMX
          References
          ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
          Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
          Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
          Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
          Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.
          Product Information
          CAS number28822-58-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₄N₄O₂
          Chemical formulaC₁₀H₁₄N₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Application3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
          Biological Information
          Primary TargetcAMP and cGMP phosphodiesterases
          Primary Target IC<sub>50</sub>2-50 µM against cAMP and cGMP phosphodiesterases
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSZD8500000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          410957-1GM 04055977211139
          410957-250MG 04055977211146

          Documentation

          3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          410957

          References

          Reference overview
          Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
          Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
          Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
          Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
          Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

          Brochure

          Title
          Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          SynonymsIBMX
          DescriptionA non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.
          FormWhite solid
          CAS number28822-58-4
          RTECSZD8500000
          Chemical formulaC₁₀H₁₄N₄O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM), Ethanol (10 mg/ml), or Methanol (50 mg/ml). Heating may be required to achieve complete solubilization.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
          Toxicity Standard Handling
          ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
          Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
          Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
          Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
          Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
          Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
          Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.