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220467
Sigma-Aldrich2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem
A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.
More>>A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
Catalogue Number
220467
Brand Family
Calbiochem®
Synonyms
2CdA, Cladribine
References
References
Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872. Robertson, L.E., et al. 1993. Blood81, 143. Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395. Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect.
S Phrase
S: 22-24/25-26-36/37/39-45
Do not breathe dust. Avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Harmful & Carcinogenic / Teratogenic
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number
GTIN
220467-10MG
04055977201116
Documentation
2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem SDS
2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem Certificates of Analysis
Title
Lot Number
220467
References
Reference overview
Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872. Robertson, L.E., et al. 1993. Blood81, 143. Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395. Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-April-2008 RFH
Synonyms
2CdA, Cladribine
Description
A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
Form
White solid
CAS number
4291-63-8
RTECS
AU7357560
Chemical formula
C₁₀H₁₂ClN₅O₃
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (5 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Harmful & Carcinogenic / Teratogenic
Merck USA index
14, 2337
References
Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872. Robertson, L.E., et al. 1993. Blood81, 143. Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395. Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
