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585970 (±)-Thalidomide - CAS 50-35-1 - Calbiochem

Selective inhibitor of TNF-α biosynthesis.

(±)-Thalidomide - CAS 50-35-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Primary Target: TNF-α biosynthesis
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      50-35-1C₁₃H₁₀N₂O₄
      Description
      OverviewSelective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
      Catalogue Number585970
      Brand Family Calbiochem®
      Synonyms(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
      References
      ReferencesGershon, D. 1995. Nat. Med. 1, 1230.
      Thompson, C. 1995. Lancet 346, 1289.
      Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
      D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
      Product Information
      CAS number50-35-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₃H₁₀N₂O₄
      Chemical formulaC₁₃H₁₀N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetTNF-α biosynthesis
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSTI4375000
      Safety Information
      R PhraseR: 21-25-46-61-62

      Harmful in contact with skin.
      Toxic if swallowed.
      May cause heritable genetic damage.
      May cause harm to the unborn child.
      Possible risk of impaired fertility.
      S PhraseS: 36/37/39-45-22-26

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      585970 0