Millipore Sigma Vibrant Logo

691550 Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: ZnPP-9

Primary Target: heme oxygenase
View Products on Sigmaaldrich.com
691550
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
15442-64-5C₃₄H₃₂N₄O₄Zn

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
691550-25MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 25 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
      Catalogue Number691550
      Brand Family Calbiochem®
      SynonymsZnPP-9
      References
      ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.
      Product Information
      CAS number15442-64-5
      ATP CompetitiveN
      FormDark red solid
      Hill FormulaC₃₄H₃₂N₄O₄Zn
      Chemical formulaC₃₄H₃₂N₄O₄Zn
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetheme oxygenase
      Primary Target IC<sub>50</sub> 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      691550-25MG 04055977225143

      Documentation

      Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      691550

      Referencias bibliográficas

      Visión general referencias
      Wolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      SynonymsZnPP-9
      DescriptionA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.
      FormDark red solid
      CAS number15442-64-5
      Chemical formulaC₃₄H₃₂N₄O₄Zn
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMF or Pyridine
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.