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681525 Wiskostatin - CAS 253449-04-6 - Calbiochem

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

Wiskostatin - CAS 253449-04-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: N-WASP (neural Wiskott Aldrich syndrome protein)
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681525
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
253449-04-6C₁₇H₁₈Br₂N₂O

Precios y disponibilidad

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681525-1MG
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      681525-5MG
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      Suspendido
      Cantidades limitadas disponibles
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          Contact Customer Service

          		 Ampolla de plást. 5 mg
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          Description
          OverviewA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
          Catalogue Number681525
          Brand Family Calbiochem®
          References
          ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
          Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
          Product Information
          CAS number253449-04-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₇H₁₈Br₂N₂O
          Chemical formulaC₁₇H₁₈Br₂N₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetN-WASP (neural Wiskott Aldrich syndrome protein)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          681525-1MG 04055977260090
          681525-5MG 04055977260106

          Documentation

          Wiskostatin - CAS 253449-04-6 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Wiskostatin - CAS 253449-04-6 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          681525

          Referencias bibliográficas

          Visión general referencias
          Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
          Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-April-2008 RFH
          DescriptionA cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number253449-04-6
          Chemical formulaC₁₇H₁₈Br₂N₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPeterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747.
          Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.