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676500 VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

The VEGFR2/Flt3/c-Kit Inhibitor, also referenced under CAS 796967-10-7, controls the biological activity of VEGFR2/Flt3/c-Kit. This small molecule/inhibitor is primarily used for Activators/Inducers a

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Sinónimos: Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII, c-Kit Inhibitor I

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676500
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CAS #Empirical Formula
796967-10-7C₂₁H₁₉N₅O

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      Description
      OverviewA cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).
      Catalogue Number676500
      Brand Family Calbiochem®
      SynonymsVascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII, c-Kit Inhibitor I
      References
      ReferencesDai, Y., et al. 2007. J. Med. Chem. 50, 1584.
      Product Information
      CAS number796967-10-7
      FormOff-white solid
      Hill FormulaC₂₁H₁₉N₅O
      Chemical formulaC₂₁H₁₉N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      676500-5MG 04055977260496