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662035 U-73122 - CAS 112648-68-7 - Calbiochem

U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils.

U-73122 - CAS 112648-68-7 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione

Primary Target: Agonist-induced phospholipase C activation
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662035
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Tabla espec. clave

CAS #Empirical Formula
112648-68-7C₂₉H₄₀N₂O₃

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      Description
      OverviewA potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases. Inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca2+ transients (IC50 = 800 nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.
      Catalogue Number662035
      Brand Family Calbiochem®
      Synonyms1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione
      References
      ReferencesStam, J.C., et al. 1998. EMBO J. 17, 4066.
      Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320.
      Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
      Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101.
      Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125.
      Wu, H., et al. 1992. Biochemistry 31, 3370.
      Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830.
      Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.
      Product Information
      CAS number112648-68-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₉H₄₀N₂O₃
      Chemical formulaC₂₉H₄₀N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationU-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils.
      Biological Information
      Primary TargetAgonist-induced phospholipase C activation
      Primary Target IC<sub>50</sub>1-2.1 µM against agonist-induced phospholipase C activation in human platelets and neutrophils; 800 nM and 500 nM, respectively, against ET-1 and parathyroid hormone-induced Ca2+ transients; 50 nM against human polymorphonuclear neutrophil adhesion
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in DMSO and ethanol; reconstitute in anhydrous DMSO or ethanol just prior to use. Following reconstitution in anhydrous chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen, and freeze (-20°C. Dried aliquots are stable for up to 6 months at -20°C. ); Reconstitute dried aliquots in anhydrous DMSO or anhydrous ethanol just prior to use.
      Global Trade Item Number
      Número de referencia GTIN
      662035-5MG 07790788052256