Millipore Sigma Vibrant Logo

613450 TOFA - CAS 54857-86-2 - Calbiochem

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.

TOFA - CAS 54857-86-2 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 5-(Tetradecyloxy)-2-furoic acid

Primary Target: Acetyl-CoA carboxylase (ACC)
View Products on Sigmaaldrich.com
613450
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
54857-86-2C₁₉H₃₂O₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
613450-5MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 5 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
      Catalogue Number613450
      Brand Family Calbiochem®
      Synonyms5-(Tetradecyloxy)-2-furoic acid
      References
      ReferencesLandree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
      Zhou, W., et al. 2003. Cancer Res. 63, 7330.
      Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
      Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
      Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
      Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
      Product Information
      CAS number54857-86-2
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₉H₃₂O₄
      Chemical formulaC₁₉H₃₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAcetyl-CoA carboxylase (ACC)
      Primary Target IC<sub>50</sub>4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      613450-5MG 04055977263787

      Documentation

      TOFA - CAS 54857-86-2 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      TOFA - CAS 54857-86-2 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      613450

      Referencias bibliográficas

      Visión general referencias
      Landree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
      Zhou, W., et al. 2003. Cancer Res. 63, 7330.
      Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
      Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
      Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
      Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-November-2014 JSW
      Synonyms5-(Tetradecyloxy)-2-furoic acid
      DescriptionA cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number54857-86-2
      Chemical formulaC₁₉H₃₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml). Slight warming and sonication may be required for complete solubilization in ethanol.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesLandree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
      Zhou, W., et al. 2003. Cancer Res. 63, 7330.
      Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
      Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
      Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
      Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.